The Me 262, however, had moderate success against the B-17 late in the war. With its usual nose-mounted armament of four MK 108 cannons, and with some examples later equipped with the R4M rocket, launched from underwing racks, it could fire from outside the range of the bombers' .50 in (12.7 mm) defensive guns and bring an aircraft down with one hit, as both the MK 108's shells and the R4M's warheads were filled with the "shattering" force of the strongly brisant Hexogen military explosive.

Me 262 pilots claimed a total of 542 Allied kills (although higher claims are sometimes made) against the loss of about 100 Me 262s. 

On March 18, 1945, Me 262 fighter units were able, for the first time, to mount large scale attacks on Allied bomber formations. 37 Me 262s of Jagdeschwder 7 (JG 7) intercepted a force of 1,221 bombers and 632 escorting fighters. This action also marked the first use of the new R4M rockets. The high explosive warhead of only one or two of these rockets was capable of downing a B-17. They shot down 12 bombers and one fighter for the loss of three Me 262s.

I don't know if this clip shows the described action above, however it looks a pretty good option to show it.